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A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility

June 18, 2023

Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility.

Agarwal A, Finelli R, Selvam MK, Leisegang K, Majzoub A, Tadros N, Ko E, Parekh N, Henkel R, Durairajanayagam D, Colpi GM, Cho CL, Sallam HN, Park HJ, Saleh R, Micic S, Ambar RF, Zini A, Tremellen K, Alvarez JG, Palani A, Arafa M, Gava MM, Jindal S, Amar E, Kopa Z, Moein MR, Busetto GM, Sengupta P, Kavoussi P, Maldonado I, Fikri J, Borges E, Martinez M, Bojovic D, Rajmil O, Aydos K, Parekattil S, Marmar JL, Sefrioui O, Jungwirth A, Peña MG, Cordts EB, Elbardisi H, Mostafa T, Sabbaghian M, Sadighi Gilani MA, Morimoto Y, Alves MG, Spasic A, Kenic U, Ramsay J, Akande EO, Oumeziane A, Dozortsev D, Chung E, Bell EG, Allegra A, Tanos V, Fiadjoe M, Gurgan T, Abou-Abdallah M, Al-Rumaih H, Oborna I, Arab H, Esteves S, Amer M, Kadioglu A, Yuzko O, Korsak V, Shah R. A

World J Mens Health. 2021 Jul;39(3):470-488. 

https://doi.org/10.5534/wjmh.210025

 CAPSULE: 
Capsule: The lack of clinical guidelines for AOX use restricts standardization in clinical protocols despite increasing attention. There is no consensus on regimen, dosing, or treatment length while the prescription practices vary globally. Our online survey evaluated the practice patterns of reproductive specialists regarding the clinical usefulness of OS tests and AOX prescriptions in male infertility. Despite low-quality scientific evidence, AOX is commonly used in treating infertile men. The reasons for low quality evidence range from: limited well-designed clinical trials with small sample sizes, inconsistent methodologies, variations in the types and doses of antioxidants studied, and lack of standardized outcome measures. Additionally, the existing studies may have methodological flaws or bias, leading to uncertainty in drawing definitive conclusions about the effectiveness of antioxidants in treating male infertility. The authors emphasize the need for clinical practice guidelines in AOX therapy for male infertility management.

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